ATM UNDEREXPRESSION Detail (hg19) (ATM)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr11:108,093,559-108,239,826 |
| hg38 | chr11:108,222,832-108,369,099 View the variant detail on this assembly version. |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| pancreatic cancer | B |
Prognostic
|
Supports
|
Poor Outcome |
N/A
|
2 | 25423555 | Detail | |
| chronic lymphocytic leukemia | B |
Prognostic
|
Supports
|
Poor Outcome |
N/A
|
3 | 9788599 | Detail | |
| cancer | KU-0060648,NU7441 | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 5 | 23761041 | Detail |
| stomach cancer | Olaparib,Paclitaxel | B |
Predictive
|
Supports
|
N/A
|
1 | 26282658 | Detail | |
| gastric adenocarcinoma | Olaparib | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 24841718 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Absent expression of ATM, as assessed by IHC in 133 pancreatic ductal adenocarcinomas, was found to ... | CIViC Evidence | Detail |
| 43 B-CLL patients with LoH or reduced protein levels (<50% normal expression, radioimmunoassay, west... | CIViC Evidence | Detail |
| ATM-deficient H1395 and HT144 cancer cell lines showed growth inhibition when treated with DNA PKcs ... | CIViC Evidence | Detail |
| A randomized phase 2 trial investigating the efficiency of Olaparib plus Paclitaxel vs. Placebo plus... | CIViC Evidence | Detail |
| Low ATM protein expression led to sensitivity to PARP inhibitors in TP53 -ve gastric cancer cell lin... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- ATM
- Genome
- hg19
- Position
- chr11:108,093,559-108,239,826
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- UNDEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000278616.4
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/179
Genome browser